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Notably, the phosphorylation of MARCKS (Myristoylated alanine rich C kinase substrate) was initiated at the earliest time point (1 month of age) in the mouse model prior to A aggregation as determined by immunohistochemistry and before the onset of cognitive impairment9. MARCKS is a submembrane protein anchoring actin cytoskeleton network and a representative substrate of protein kinase C (PKC)10. However, the phosphoproteome analysis was based on integrating the values of all of a protein’s phosphorylation sites.
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